New Paper: Single-Color Barcoding for Multiplexed Hydrogel Bead-Based Immunoassays

The ACS journal of Applied Material Interfaces recently published a paper from CPI entitled: Single-Color Barcoding for Multiplexed Hydrogel Bead-Based Immunoassays. This paper offers a new and efficient method for fabricating barcoded, functionalized hydrogel beads.

Barcoded hydrogel beads nowadays are often used in precision medicine to simultaneously detect various biomarkers in, for instance, blood samples.  The simultaneous analysis of various biomarkers, as compared to single biomarker analysis, allows for detection of more disease-specific information. This can in turn lead to more effective therapies.

In order to simultaneously detect various biomarkers, researchers have proposed the usage of immunoassays on barcoded hydrogels beads—however encoding/decoding the barcodes is a complex and resource intensive process.  

This paper aims to address this challenge by offering a “straightforward strategy to incorporate optical barcodes into biofunctionalized hydrogel beads for simple and efficient encoding and decoding” as tool for multiparametric approaches.

To read more about this new method, check out the full article (available via Open Access) here:https://pubs.acs.org/doi/full/10.1021/acsami.2c04361