Thin hydrogel coatings are platelet repellent
Four groups have contributed to a project on hydrogel coatings as platelet repellent surfaces. This work has now been published by the ASAIO Journal.
Maral Baghai has taken hydrogel coatings developed at CPI and studied the adhesion of platelets on these surfaces as a function of the swelling behavior of the materials.
Many of these experiments were inspired through the collaboration with the Departments of Cadiovascular Surgery and the Laboratory of Hemostaseology at the Department of Pediatrics and Adolescent Medicine at the University Hospital Freiburg.
Blood tests were performed at the Division of Cardiology at the Tokai University School of Medicine.
The results are consistent with earlier investigations on hydrogel coatings. Gels that swell significantly in an aqueous environment repel any proteins which renders the surfaces inert against the attachment of cells and also for blood platelets.
The publication is currently available "ahead of print":
Maral Baghai, Noriko Tamura, Friedhelm Beyersdorf, Michael Henze, Oswald Prucker, Jürgen Rühe, Shinya Goto, Barbara Zieger, Claudia Heilmann
Platelet repellent properties of hydrogel coatings on polyurethane coated surfaces
ASAIO Journal, (published ahead of print)
DOI: 10.1097/MAT.0000000000000118
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