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Seminar: Plasma Activated Biointerfaces by Prof. David R. McKenzie

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Prof. David McKenzie from the Applied and Plasma Physics group of the School of Physics at the University of Sydney will visit the IMTEK on August, 2nd. He will present aspects of his research at 2pm in Rm 101 02 016/18 (conference room).

What
  • Talk Prof. McKenzie
When Aug 02, 2013
from 02:00 PM to 03:30 PM
Where Rm 101 02 016/18
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Plasma Activated Biointerfaces

Professor DR McKenzie

Plasma immersion ion implantation of polymers induces a capability for the formation of covalent bonds with biological molecules adsorbed on the surface. A model based on the creation of a radical rich modified layer which acts as a reservoir of radicals has been developed. It is proposed that the diffusion of radicals from the modified layer to the surface is responsible for the formation of covalent bonds. The model gives good agreement with the observed kinetics and predicts that the surfaces can remain active for long periods. The same phenomenon is observed for plasma polymers deposited under bias conditions, enabling any surface to be provided with a covalent binding capability. The covalent binding appears to operate on all amino acids, so that all proteins, enzymes  and peptides can in principle be used to functionalise a surface. Examples of the use of plasma activation to produce surfaces  for controlling the reaction of the body to implanted devices and materials will be presented. These include cardiovascular stents and spinal implants where cell recruitment is of importance in the subsequent operation of the device. The methods have also been used to functionalise polymer sheets and granules with enzymes for industrial processing. An example will be given of the binding of enzymes useful in the production of ethanol as a biofuel from cellulosic waste.

» Applied and Plasma Physics group @ U Sydney

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